Toxic Fat Accumulation Responsible for Type 2 Diabetes

While it may be unsurprising to learn that fat buildup can cause type 2 diabetes, a study has helped clarify the issue further by proving that toxic fat is specifically responsible for this problem. So, it’s not all kinds of fat that cause type 2 diabetes.

This should come as a relief to obese and overweight people concerned that sooner or later they will find themselves dealing with diabetes or prediabetes simply because they have excess fat in their bodies. Diabetes ails an estimated 30 million Americans, and over 90% of these suffer from type 2 diabetes. This is why Nutrisystem developed a plan, known as Nutrisystem D, to help overweight diabetic patients lose weight and manage their diabetes. For Nutrisystem have a peek on this web-site.

Diabetes is a major risk factor for type 2 diabetes. In fact, only about 12% of diabetics have normal weight. Surprisingly, previous findings showed that diabetes was more fatal to people of normal weight than to overweight and obese people. This was a curious observation, and this study might just have given us the answer.

The research, conducted by Scott Summers, a professor at the University of Utah, has proposed, based on a study done by him and his team, that toxic fat metabolites by the name of ceramides might be responsible for type 2 diabetes. The experiment was conducted on mice, and it indicated that the buildup of these toxic fats impaired normal fat tissue function.

Of the fats people consume, some end up getting stored, while others are burned to provide energy. Unfortunately, for some people, some of the fats turn into ceramides, which accumulate and then interfere with the body’s ability to respond to insulin and burn calories. Type 2 diabetes is caused by an impaired response to insulin, while Type 1 diabetes results from insufficient insulin production.

Apparently, there is a stage at which these ceramides reach dangerous levels in the body. At these levels, they interfere with the working of the fat tissue. Continued build up eventually causes this toxic fat to spill to other parts of the body, where it causes more damage.

But this is hardly the first time ceramides have been linked to type 2 diabetes. In previous studies, it has been noticed that they increase insulin resistance, suppress the expression of the insulin gene, and even cause pancreatic beta cells to die.

Of the mice exposed to more ceramides, there was an increased insulin resistance and higher likelihood of experiencing fatty liver disease and diabetes. So, the link between obesity and type 2 diabetes is a little more complex than most people thought. Which may explain why Asian countries, despite having lower obesity levels, have higher rates of diabetes than the US, despite its higher obesity levels.

Meanwhile the accumulation of ceramides had already been linked to things like genetics and ethnicity. Apparently, some people can accumulate fat, become overweight and obese, and still escape the risk of obesity. The Summers team is now working on a drug capable of suppressing production of ceramides in the body, which might prevent type 2 diabetes in people predisposed to acquiring it because of their propensity to produce and accumulate these toxic fats.

 

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